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Immune-Building Supplements

Six Considerations for Immune Building Supplements.

Taking proactive steps to care for your immune system will result in it taking exceptional care of you!

Six Key Considerations for Powerful Immune-Boosting Supplements

A strong immune system is your best defense against illness, significantly reducing how often you get sick. When your immune system is finely tuned, it acts as a vigilant guardian, tackling potential health issues before they can take hold.

Even if you do fall ill, a robust immune system ensures a quicker recovery and less severe symptoms. Moreover, when your immune system operates at its best, you’ll feel more energetic and vibrant, free from the burdens of hidden infections or chronic inflammation.

So, how can you cultivate a resilient immune system?

Many individuals are turning to dietary supplements for support. Even a well-rounded diet may not deliver all the nutrients necessary for optimal immune function. Quality supplements can bridge these nutritional gaps, ensuring your body receives the essential nutrients it needs to build a robust immune system and maintain overall health. However, the right choice is crucial—navigating the myriad products and strategies available can be overwhelming, but the right supplement can make all the difference in enhancing your well-being.

Six Considerations Before Choosing Immune-Boosting Supplements

  1. Herbs, Vitamins, or Specialty Supplements?

When it comes to immune-boosting supplements, there are three main categories to consider: herb mixtures, vitamin mixtures, and specialty formulations.

Herbs and Vitamins: Claims about the immune benefits of vitamins and herbs are often based more on historical beliefs than on scientific evidence. These supplements are minimally regulated, which means their potency and effectiveness can vary significantly. As a result, it can be challenging to determine which positive outcomes are actually achievable and consistent.

Specialty Formulations: In contrast, specialty supplements are specifically formulated to enhance particular health outcomes. They are more likely to provide greater bioactive potency and are developed based on solid scientific research.

  1. How Many Immune-Boosting Mechanisms Are Included?

Specialty formulations often combine multiple ingredients that have been proven effective in peer-reviewed studies. The rationale behind using several ingredients is that if each one can independently support immunity, a combination may be even more effective. Each ingredient serves a specific purpose, and the synergy among them can enhance their overall effectiveness.

  1. Consider Humane Animal or Human Testing

Validating a product’s efficacy through testing is essential. Large mammals, like pigs, share many biological similarities with humans, making humane animal testing a valuable consideration. Look for studies from manufacturers that support their claims regarding benefits, as the presence of these studies is a positive sign.

The longer a product has been safely used, the more confidence you can have in its reliability.

  1. Safety and Manufacturing

A long history of safe use is reassuring. The FDA regulates both finished dietary supplement products and their ingredients under different regulations than those for conventional food and drugs. Manufacturers and distributors of dietary supplements are prohibited from marketing products that are adulterated or misbranded. This puts the responsibility on them to evaluate the safety and labeling of their products before they reach the market, ensuring compliance with the Federal Food, Drug, and Cosmetic Act, as amended by the DSHEA and FDA regulations.

  1. Potency

When comparing products, check the bioactive concentration listed on the label’s “Supplement Facts” grid. This information allows you to assess the comparative potency of different products. Generally, those with higher potency are more expensive but also more effective. Remember that the form of the ingredient, dosage, and overall formulation can all impact the effectiveness of a dietary supplement. In the long run, you may find that more expensive options offer better value.

  1. Comparison Shopping: Immune Building Supplements

Comparison shopping is essential for making informed decisions and avoiding impulse buys based solely on marketing claims. This practice helps prevent buyer’s remorse and ensures you get the best value for your money. A lower price often indicates lower-quality ingredients, but this doesn’t necessarily mean the product will be effective. Specialty formulations, typically priced higher, tend to perform better.

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Strengthen Your Immune Defenses

Strenthen Your Immune Defenses.

Strengthen Your Immune Defenses

As writer Augusten Burroughs noted,

“When you have your health, you have everything. When you do not have your health, nothing else matters at all.”

While opinions on this statement may vary, it’s hard to deny that illness or poor health can significantly impact what would otherwise be a happy, productive, and fulfilling life.

A robust immune system is crucial for maintaining optimal health. For individuals who may be at greater risk of disease due to weakened immune systems, we at CortControl offer a solution that has been proven to be both effective and safe.

Glutrasol supports a balance of cytokines, which are a specific type of protein.

The science behind this is straightforward. Cytokines can become imbalanced for various reasons, including stress, fatigue, or an individual’s natural chemical makeup. When this occurs, the immune system can become weakened, increasing the risk of illnesses such as the flu, travel-related illnesses, heart disease, Lyme disease, respiratory infections, diabetes, and even certain forms of cancer. Cytokine Balance Supports Immune Health.

Glutrasol is a reliable solution.

Glutrasol is a reliable solution. Glutrasol helps restore cytokine balance, thereby strengthening the body’s immune defenses and providing a shield against potential health risks. Balanced Cytokines Aid Prevention.

Unlike conventional nutraceuticals and other supplements, Glutrasol is more than just a mixture of vitamins and herbal extracts. It is a complex formulation containing 18 innovative bioactives that have been:

  • Clinically studied
  • Supported by numerous published scientific papers from both industry and academia
  • Tested for over 30 years in various veterinarian-supervised animal studies

Strengthen Your Immune Defenses

Glutrasol is safe. It is not a drug and does not contain genetically modified ingredients. This formulation is sustainable, naturally occurring, and free from side effects. Additionally, it is non-invasive. Glutrasol typically comes in powdered form and can be mixed with juice or another beverage for consumption.

If you want to reduce the risk of certain diseases and enhance your chances of maintaining good health by strengthening your immune defenses, Glutrasol may be the solution you need to continue or return to a happy, productive, and fulfilling life.

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Specialty Nutraceuticals and Pharmacists’ Role

Specialty Nutraceuticals and Pharmacists.

4 Reasons Pharmacists Should Expand Their Knowledge of Specialty Nutraceuticals

In an article published in the Journal of the American Pharmacists Association, Norman V. Carroll, Ph.D., presented the findings of a study that confirmed a long-held belief in the healthcare and pharmaceutical industries regarding the role of community pharmacists. The study concluded that:

  1. Pharmacists often recommend to physicians that they initiate, discontinue, or modify specific drug therapies.
  2. These recommendations are typically made to address clinical issues or to offer patients more affordable options.
  3. Pharmacists tend to be successful in persuading physicians to adopt their suggestions.

This highlights the significant influence pharmacists have on the prescription process. However, with this influence comes a considerable responsibility to carefully consider emerging treatment options. One area that warrants further exploration is specialty nutraceuticals.

What Are Nutraceuticals?

Nutraceuticals are generally defined as substances in food or components of food that provide medicinal or health benefits, including the prevention and treatment of diseases. This category encompasses a diverse range of products, including dietary supplements, isolated nutrients, herbal supplements, and specialized food items. Research indicates that approximately 77% of Americans use nutritional supplements, including over 70% of adults aged 60 and older. Given the increasing variety and use of nutraceuticals, both potential benefits and risks are associated with these products.

As the nutraceutical market continues to grow and gain popularity among consumers, pharmacists have an opportunity to enhance their expertise and solidify their roles as vital healthcare providers.

4 Reasons Pharmacists Should Learn More About Specialty Nutraceuticals

  1. Understanding Integrated Health Systems and Treatment Options

Pharmacists need to be well-informed about integrated health systems and the treatment options available to patients. Many, including pharmacists, may be unclear about the specialty of nutraceuticals. Some might mistakenly think it refers to a trendy line of health foods, herbal remedies, or vitamin supplements. However, this assumption is incorrect.

According to the 1988 amendments to the FDA’s Orphan Drug Act, medical food is defined as “intended for the specific dietary management of a disease or condition for which distinctive nutritional requirements, based on recognized scientific principles, are established by medical evaluation.”

Specialty nutraceuticals are dietary products that support specific bodily structures or functions. They do not replace drugs or traditional medical treatments; rather, they are part of integrative medicine, which safely and effectively supports immune health and other conditions. For more information from the FDA on specialty nutraceuticals, visit the Dietary Supplements Guidance Documents and Regulatory Information section.

  1. Significant Benefits Over Other Treatment Options

In many cases, specialty nutraceuticals provide significant advantages over conventional treatment options. Unlike many pharmaceuticals, these products typically do not have side effects or high price tags. They can often serve as a first-line treatment for various indications, allowing patients to avoid potential side effects and costs associated with traditional medications.

  1. Helping Millions of People

Current drug development and treatment strategies often treat large patient populations as homogeneous groups, failing to consider individual differences among patients. Specialty nutraceuticals enable pharmacists and healthcare providers to customize or “fine-tune” treatments to address the distinct needs of individual patients.

This customization supports improved immune health and empowers pharmacists in their commitment to provide the best solutions for clients who rely on their expertise and sound judgment.

Learning about dietary supplements and specialty nutraceuticals is essential for pharmacists to enhance their practice and better support their patients’ health.

Dietary Supplements: What Pharmacists Should Know

Learn More

To learn more about medical foods, visit the FDA’s Dietary Supplements Guidance Documents and Regulatory Information.

CortControl develops and markets patented specialty nutraceuticals, including Glutrasol and Transfer Factor Ultra. These products are designed to support fertility, immune health, and overall well-being.

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Integrative Medicine

Integrative Medicine: Solid evidence is key.

Solid Evidence Is Key: Integrative Medicine

Integrative medicine is an approach to healthcare that acknowledges the benefits of combining conventional therapies, such as drugs and surgery, with complementary therapies like acupuncture, yoga, and specialized nutraceuticals that are safe and effective.

In recent years, the concept of “integrative medicine” has gained popularity as a treatment approach that combines traditional medical practices with evidence-based complementary and alternative remedies. This approach aims to treat the whole person rather than just addressing a specific disease.

Integrative medicine can also help strengthen your immune system.

Often referred to as “holistic medicine,” “complementary medicine,” or “complementary and alternative medicine” (CAM), integrative medicine was once considered a fringe approach. However, it has rapidly gained acceptance within the mainstream medical community.

Solid Evidence: A Critical Component of Integrative Medicine

Surveys conducted by the American Hospital Association indicate a significant increase in the number of U.S. hospitals offering complementary therapies, rising from 9% in 1998 to 42% in 2011.

Academic Health Centers

Over 60 academic and professional medical centers in the U.S., Canada, and Mexico have formed the Consortium of Academic Health Centers for Integrative Medicine. This consortium aims to promote integrative medicine throughout North America and includes renowned institutions such as Harvard, Yale, Stanford, Duke, the University of Southern California (USC), and the University of Michigan.

Doctors’ Lingering Doubts

Despite the growing practice of integrative medicine, many doctors still have concerns. In a hospital survey, for instance, 44% of respondents identified “physician resistance” as one of the three main barriers to the adoption of integrative medicine programs.

Numerous doctors cite the lack of scientific evidence as a reason for their hesitance. Dr. Tom Delbanco of Harvard Medical School expressed this concern, stating, “I worry that people are making claims in the context of scientific medicine that they cannot really justify. There have been few rigorously controlled, scientifically sound studies in this area.”

The Importance of Solid Evidence in Integrative Medicine

While perspectives on integrative medicine may vary among doctors, there is a consensus on the necessity of thorough scientific research and reliable evidence. Here are some critical questions to consider:

  • Was the testing controlled and double-blind?
  • Was the sample group representative of the larger population?
  • Were there biases present in the testing procedures?
  • Were the conclusions drawn from the data appropriate and not overstated?
  • If a mean result is reported, what is the confidence interval for that mean?
  • What is the probability that any observed differences are due to chance?

It is entirely reasonable to ask these questions. When there is strong scientific evidence supporting a specific integrative therapy, doctors are more likely to consider it.

Unfortunately, much of the ongoing discussion surrounding integrative therapies focuses on treatments like herbs or meditation, which often lack solid evidence to support claims of effectiveness.

Considering the Specialty Nutraceuticals Option

Doctors who require evidence-based solutions have another option: specialty supplements. Although still unfamiliar to many in the healthcare field, these dietary products are designed to support specific physiological structures and functions. They are not substitutes for medications or traditional medical treatments; instead, they complement an integrative medical approach, safely and effectively addressing diseases and various health conditions.

Learn More

To gain more information about medical foods, please visit the FDA’s Dietary Supplements Guidance Documents and Regulatory Information.

Health & Wellness

While integrative medicine is rapidly gaining acceptance in the medical community, it remains a relatively new treatment approach. This method holds significant promise, but it also warrants some skepticism. The key challenge is to differentiate between effective options and those that may be ineffective or even harmful.

A good starting point for this evaluation is to consider options that have demonstrated their value and received FDA approval.

CortControl develops and markets patented specialty nutraceuticals, including Transfer Factor Ultra and Glutrasol. These products are designed to support fertility, immune health, and overall well-being.

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Improve Your Athletic Ability

Improve your athletic abiltiy.

Enhance Your Athletic Performance

Are you an athlete looking to perform at your best in your next event? Whether you want to achieve faster times, cover longer distances, score more goals, or recover quickly afterward, the answer is likely “yes.” Remember, enjoyment and performance in sports are closely linked.

Whether you’re an elite Ironman competitor or a casual exerciser, your immune system is crucial to your athletic performance. It not only helps prevent illness but also affects your overall ability to perform effectively.

Extreme Athletes

Extreme athletes understand the intense demands of training, sleep, performance, and recovery. The lead-up to an event can cause mental stress, draining energy and negatively impacting sleep quality, which in turn affects performance. Post-event recovery takes time, and you may be more vulnerable to illness for about five days.

Enthusiastic Athletes

As an enthusiastic athlete, your experience may differ from others. Moderate exercise boosts your immune system, but there’s always room for further improvement in performance.

The difference between extreme and enthusiastic athletes is summarized

Bente Klarlund Pedersen and Anders Dyhr Toft from the Copenhagen Muscle Research Centre and the Department of Infectious Diseases explain the difference between extreme and enthusiastic athletes.

They state, “Moderate exercise across the lifespan seems to increase resistance to upper respiratory tract infections, whereas repeated strenuous exercise suppresses immune function.”* 

*Effects of exercise on lymphocytes and cytokines.

The key to supporting extreme and enthusiastic athletes is to strengthen and enhance the immune system.

To begin with, let’s cover some basics. Your immune system is composed of immune cells and immune proteins (technically known as cytokines). Immune cells include macrophages, often referred to as “big eaters.” These cells play a crucial role in protecting us by consuming viruses, fungi, and bacteria.

Immune proteins serve as the regulators of the immune system, directing its actions. They function most effectively when they are balanced; any imbalance can lead to issues.

Additionally, immune proteins connect the immune system to the central nervous system. They help to facilitate the release of regulating hormones, which can impact various everyday performance issues.

Importantly, immune proteins can be increased and balanced, contributing to overall health and performance.

Balancing immune proteins is an effective way to enhance the immune system’s strength.

A diet alone may not provide the necessary immune proteins for this balance. This is where Glutrasol comes in. This performance supplement enhances immune protein balance in two key ways.

First, balanced cytokines are injected directly into the digestive tract, where they remain stable before being absorbed through the intestinal wall. Second, the body produces even more balanced cytokines, which help replace any missing immune proteins. See:

By using specialized nutraceuticals, you can enhance your athletic performance.

All athletes can experience significant improvements as immune protein balance is restored, leading to increased energy levels and an overall sense of well-being. Stamina replaces mere endurance, and motivation comes easily when you feel good.

For extreme athletes, recovery is swift, and the risk of respiratory infections is reduced.

Enjoy reaching your new athletic potential! The choice of whether to share this with your competitive friends is up to you!

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Medical Foods

Medical Foods.

As patients explore personalized treatment options, healthcare providers should do the same.

Healthcare treatment is rapidly evolving. Increasing numbers of consumers are showing interest in an approach known as “integrative medicine.” This approach offers new possibilities for enhanced and personalized patient care.

Integrative medicine is not entirely new; its principles are straightforward and sensible. Rather than relying solely on a one-dimensional approach, such as simply “taking this pill three times a day,” integrative medicine suggests that the best healthcare solutions may involve a combination of medications and complementary remedies. These can include a balanced diet, regular exercise, vitamins, and FDA-approved specialty nutraceuticals.

What are specialty nutraceuticals, or medical foods?

Specialty nutraceuticals are dietary products specifically designed to support particular bodily structures or functions. The term broadly refers to any product derived from food sources that provides additional health benefits beyond the basic nutritional value found in foods.

While terms like “exercise” and “vitamins” are commonly understood, “specialty nutraceutical” may be unfamiliar to many in the healthcare field. It’s essential to note that nutraceuticals are not substitutes for traditional drugs or medical treatments; instead, they are part of an integrative approach to support health issues safely and effectively.

What is the difference between a nutraceutical and a medicine?

Pharmaceuticals are FDA-approved drugs specifically designed to treat diseases and provide immediate relief. In contrast, nutraceuticals are nutrient-rich dietary substances derived from whole foods or parts of food sources that offer health benefits beyond basic nutrition.

To learn more, visit the Dietary Supplements Guidance Documents and Regulatory Information page on the FDA’s website.

Doctors and pharmaceutical companies are slow to adapt to specialty nutraceuticals.

Although consumer interest in specialty nutraceuticals is on the rise, many doctors and pharmaceutical companies remain hesitant to embrace them. A recent survey by the American Hospital Association found that 44% of respondents identified “physician resistance” as one of the top three barriers to adopting integrative medicine programs that may include specialty nutraceuticals.

Additionally, some pharmaceutical companies view these supplements not as an opportunity to serve their customers and explore a new revenue stream, but rather as a threat to their existing businesses. This resistance from the pharmaceutical sector is unfortunate, as specialty nutraceuticals offer promising new options for both doctors and patients, as well as a significant market opportunity for these companies.

Although the process may be slow, the specialty nutraceutical market is expected to grow in the coming years, offering patients more solutions and treatment options.

Nutraceuticals occupy a space between food and pharmaceuticals.

They include foods and substances, or combinations of substances, made up of natural molecules or elements. Nutraceuticals are used to maintain or improve health, as well as to treat or prevent diseases and conditions.

To benefit consumers, pharmaceutical companies can take the following steps:

  1. Recognize the increasing consumer interest in personalized treatments and advocate for these options.
  2. Consider specialty nutraceuticals as valuable additions to their product lines, providing a clear competitive advantage.
  3. License patented specialty supplements that are already FDA-approved for manufacturing and distribution in their core markets. Since these products are FDA-approved, research and development costs are minimal, and the time to market is significantly reduced.
  4. Produce and offer products with substantial profit margins.
  5. Assist physicians and clinics in refining their treatment protocols, enabling them to differentiate themselves more effectively in the market.

Medical Foods: The concept of personalized treatment has become increasingly relevant.

Medical foods play a crucial role in this emerging standard and perspective. This new approach presents a unique opportunity for large pharmaceutical companies to connect with customers and enhance their profits. Meeting the rising consumer demand aligns with the interests of doctors who wish to provide more options for their patients, as well as pharmaceutical companies looking to strengthen their competitive advantage.

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Specialty Nutraceuticals and Fertility

Specialty Nutraceuticals and Fertility. Doctors and nutritionists can now offer patients a valuable comprehensive fertility support program.

Supporting Fertility for More People

For years, cost has been a significant barrier for couples seeking fertility support. A recent study by the University of California, San Francisco (UCSF) revealed that couples pursuing in vitro fertilization (IVF) incur an average out-of-pocket expense of $19,234.

In the U.S., this amount represents approximately 44% of the annual disposable income for couples seeking treatment. As UCSF infertility specialist James F. Smith, MD, has noted, “For many patients, the high costs … represent a significant burden on household finances and almost certainly play a major role in fertility treatment decision-making.”

The Specialty Nutraceutical Option

Recent developments in specialty nutraceuticals may offer doctors and nutritionists a valuable new option to provide their patients with a strong first step in a comprehensive fertility support program.

Moreover, these nutraceuticals present pharmaceutical companies with new opportunities to expand their product portfolios and market reach, with a focus on fertility support. Given the significant financial burden associated with traditional treatments for many couples, exploring the right nutraceutical could be a viable option for both doctors and pharmaceutical companies.

Specialty Nutraceuticals and Fertility Treatment

Why Consider Specialty Nutraceuticals?

Although there is some skepticism surrounding specialty nutraceuticals, an increasing amount of evidence suggests that they may be more effective than traditional fertility drugs and treatments. Additionally, they are often much more affordable.

For more information, visit the Dietary Supplements Guidance Documents and Regulatory Information page on the FDA’s website.

CortControl’s Specialty Nutraceuticals

At CortControl, we offer specialty nutraceuticals like Glutrasol and Transfer Factor Ultra. For over 20 years, veterinarians have prescribed many of our essential compounds to treat various diseases and conditions in mammals. The success of these treatments is well-documented and often dramatic. For instance, fertility in cattle has increased by more than 70% in some cases.

We are confident that our supplements can make a positive difference in the lives of humans, supported by scientific evidence. All mammals, including humans, share a similar mechanism for cortisol production. When the body produces excessive amounts of cortisol, it can lead to an increased risk of infertility in some cases.

Managing Cortisol Production Is Crucial

Products like Glutrasol and Transfer Factor Ultra are designed to help control high levels of cortisol. These compounds are similar to those that veterinarians have prescribed to cattle for years to enhance fertility. We believe that they may have a comparable effect on humans.

Cortisol Stress Hormone.

Cortisol is a stress hormone that can impact fertility in both men and women.

In women, stress triggers the brain to produce cortisol, which can disrupt the function of the ovaries and the release of eggs.

Hormonal Balance: Elevated cortisol levels can disrupt the hormonal balance necessary for egg maturation. It can also decrease estradiol, potentially harming egg quality.

Ovulation: Cortisol can disrupt the signaling between the brain and the ovaries, leading to delayed or prevented ovulation.

Menstrual Cycle: High cortisol and prolactin levels can impair the regularity of the menstrual cycle.

Blood Flow: Cortisol can reduce blood flow to reproductive organs, including the ovaries.

Additionally, cortisol can suppress reproductive hormones, resulting in irregular ovulation, anovulation, and amenorrhea.

Ovulation is the process by which an ovary releases an egg that can be fertilized by sperm, potentially leading to pregnancy.

Anovulation, or an anovulatory cycle, is a medical condition in which an egg is not released from the ovaries during a menstrual cycle.

Amenorrhea refers to the absence of menstruation in a woman who usually has regular periods, lasting three months or more, or six months or more if she has had at least one spontaneous period before.

The stress hormone cortisol affects male fertility.

Specifically, it can affect sperm production and motility. Follicle-stimulating hormone (FSH), which is released by the anterior pituitary gland in response to gonadotropin-releasing hormone (GnRH), plays a crucial role in stimulating sperm production. In men, FSH helps regulate the quantity of sperm produced by the testicles and influences sperm health.

GnRH prompts the testicles to produce testosterone. Additionally, stress can lead to behavioral changes that negatively affect fertility, such as a decreased sex drive and lack of motivation. While occasional stress might not significantly impact fertility, chronic stress can result in hormone imbalances that make conception more challenging.

What is the Role of Nutraceuticals in Fertility?

Nutraceuticals are increasingly recognized as a popular method for addressing male fertility issues related to pre-testicular, testicular, and post-testicular factors.

Pre-Testicular Factors: These are also known as extra-gonadal endocrine disorders. They originate outside the reproductive system and can hinder the testes from receiving the necessary support for functioning properly. These disorders often affect spermatogenesis (the production of sperm) and can stem from issues in the hypothalamus, pituitary gland, or adrenal glands.

Testicular Factors: These factors can arise from various conditions, including varicocele-induced damage, undescended testes, testicular torsion, mumps orchitis, and the gonadotoxic effects of certain medications (such as chemotherapy, radiation, and surgical procedures). Genetic abnormalities and idiopathic causes (issues of uncertain origin) can also contribute to testicular problems.

Post-Testicular Factors: Infertility related to post-testicular factors occurs after sperm production and mainly involves blockages in the ducts leading away from the testes. These blockages can develop anywhere within the male reproductive tract.

Nutraceuticals contain a variety of nutritional components that enhance metabolic activity, regulate hormonal profiles, and support sperm production, thereby helping to mitigate these fertility issues.

Nutrition plays a crucial role in fertility.

Continuously supplying your body with the right supplements can impact your metabolism, hormones, and the entire endocrine system, all of which regulate fertility. A healthy, well-balanced diet, along with the appropriate supplements, can enhance fertility for both men and women.

Healthy Well Balaced Diet.

It’s important to consider this closely. We are not suggesting that specific nutraceuticals, such as Glutrasol and Transfer Factor Ultra, are cure-all solutions. However, we are highlighting that they show promise in supporting fertility at a relatively low cost, and are worth considering as part of a comprehensive fertility support strategy. This approach can help more individuals take advantage of infertility treatments.

A New Approach to Supporting Fertility

Glutrasol and Transfer Factor Ultra are unique, patented, science-based supplements that offer a fresh perspective on fertility support. They are specifically designed to address compromised immune function caused by elevated stress, which is a factor in an estimated 30% of fertility issues in both women and men.

Consider enhancing your fertility with Glutrasol and Transfer Factor Ultra if you:

  • Are a couple facing fertility challenges
  • Have known stressors that may be inhibiting your fertility
  • Could benefit from reducing the impact of stress on your fertility
  • Are you looking for a natural, non-invasive, and cost-effective fertility aid to improve your chances of conception

Some specific positive outcomes may include:

  • A significant increase in egg health
  • An increase in the number of healthy eggs produced
  • An increase in sperm count

CortControl is the developer and marketer of these patented specialty nutraceuticals. Their products, Glutrasol and Transfer Factor Ultra, support fertility, immune health, and address other health concerns.

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Biochemistry of Transfer Factor: Technical Paper

Biochemistry of Transfer Factor. Female scientist looking under microscope doing analysis of test sample.

I. Introduction

The Glutrasol and Transfer Factor Ultra products contain three main ingredients:

Transfer Factor: This is a chemical derived from humans or animals that have already developed immunity against a specific disease.

Glucans: Glucans are polysaccharides made from D-glucose and are linked by glycosidic bonds. They are categorized into two forms: alpha-glucans and beta-glucans.

Lactic Acid-Generating Bacteria: This group includes Gram-positive, non-respiring, non-spore-forming bacteria, either cocci or rods, that produce lactic acid as the primary byproduct of carbohydrate fermentation.

This disclosure focuses on the biochemistry of Transfer Factor. 

The effectiveness of Glutrasol and Transfer Factor Ultra is demonstrated by test groups that consistently show significant improvements compared to control groups.

Here is information on how (biochemically) they work.

II. Inducer/Suppressor Fraction of Transfer Factor

T-lymphocytes produce transfer factors and can transfer the ability to recognize a pathogen to cells that have not been previously exposed to the pathogen. They also heighten the immune system’s ability to react (increased reactivity or inducer function) to pathogens. Transfer factor produces a trigger for T-cell recognition of an antigen.

The transfer factor is a mixture of peptides, typically with a molecular weight < 10,000 Daltons. It’s more appropriate to speak of “transfer factors” instead of “transfer factor.” Fortunately, today’s preparative methods produce consistent mixtures, resulting in repeatable responses.

Fractions within the mixture serve different (and sometimes opposite) purposes. Two significant fractions are (1) the inducer fraction and (2) the suppressor fraction [1][2]. Opposing functions were confirmed using the direct Leucocyte Migration Inhibition (LMI) test.

These two fractions are consistent with field observations that the transfer factor balances the immune system.

For example:

  1. The inducer fraction of transfer factor biochemistry links the immune cells with an antigen-binding site, thereby increasing their reactivity to an antigenic stimulus. This is advantageous when a higher immune response is required. CortControl’s enhanced vaccine response arises from an inducer fraction. Several researchers have documented the inducer effects of transfer factors [3][4][5].
  2. The suppressor fraction blocks the response of the T-cells and signals a down-regulation of the immune response. This is helpful in allergic or autoimmune conditions. Animal studies demonstrate improvement in cases where the immune system is overactive. This arises from the suppressor fraction. Cortesini R. et al. [6] showed that CD8+CD28-Ts represent a unique subset of regulatory cells within the transfer factor that initiates a suppressive loop. Filaci [7] supported Cortesini’s work and related autoimmune diseases to the absence of CD8+ suppressor T lymphocytes. Filaci further found that “CD8+ Ts can be generated in vitro from CD8+CD28-T lymphocytes. A key role in their generation is played by monocytes that secrete interleukin-10 (IL-10) after granulocyte macrophage-colony-stimulating factor (GM-CSF) stimulation.”

Aleli Salazar-Ramiro et al. [8] view cancer as an autoimmune disease and propose a transfer factor for cancer therapy. This is supported by CortControl’s veterinary work on horses, dogs, and cows [9], where cancer symptoms were visibly reversed.

III. TH1/TH2 Helper Cells and Cytokines

Reviewing the helper lymphocyte paradigm helps categorize the applications of transfer factor. Helper lymphocytes develop along two cell populations: TH1 and TH2. Transfer factors from both lymphocyte lines are represented in the transfer factor biochemistry. TH1 and TH2 cells perform distinct functions and produce distinct cytokines, proteins that serve as messenger molecules.

Cell-mediated or TH1 helper responses are crucial to the body’s ability to defend itself against viruses, fungi, parasites, cancer, and other intracellular organisms. TH1 cells modulate cell-mediated immunity.

TH1 cells produce the following cytokines:  

  • IL-2,  
  • IFN-gamma, and
  • TNF-alpha

TH2 cells modulate humoral immunity (antibody production).

TH2 cells produce the following cytokines:

  • IL-4,
  • IL-5,
  • IL-6,
  • IL-10, and
  • IL-13

Cytokines are functionally similar to hormones but are not associated with a specific gland.

They appear to operate as keys and templates.

  • Cytokines are a broad and loose category of small proteins essential in cell signaling. Due to their size, cytokines cannot cross the lipid bilayer of cells to enter the cytoplasm; therefore, they typically exert their functions by interacting with specific cytokine receptors on the target cell surface.

Stereochemistry is important.

What is stereochemistry in simple terms?

  • A branch of chemistry that deals with the spatial arrangement of atoms and groups in molecules.
  • The spatial arrangement of atoms and groups in a compound and its relation to the properties of the compound.

The attachment of a cytokine to an immune cell receptor starts a specific immune signal within the target cell. Signals translate into direct action, increase the production of antibodies against an invading virus, or initiate the production of other cytokines to propagate the signal.

IV. TH1/TH2 Predominant Phenotypes 

One aspect of immune regulation involves homeostasis between T-helper 1 (Th1) and T-helper 2 (Th2) activity [10]. TH1/TH2 balance correlates with good health, and over-activation in either direction sets the stage for disease.

Th1 and Th2 helper cells direct different immune response pathways and produce different cytokines. Either pathway can downregulate the other.

Steven Bock, MD, correlated disease conditions to an imbalance of TH1 and TH2. For example, if one has a TH2-dominated condition, the disease conditions that tend to prevail are:

  1. Allergies
  2. Chronic sinusitis
  3. Atopic eczema
  4. Asthma
  5. Systemic autoimmune conditions such as lupus erythematosus and mercury-induced autoimmunity
  6. Vaccination-induced state
  7. Certain cases of autism
  8. Hyperinsulinism
  9. Pertussis vaccination
  10. Malaria
  11. Helminth infection
  12. Hepatitis C
  13. Chronic giardiasis
  14. Hypercortisolism
  15. Chronic candidiasis
  16. Cancer
  17. Viral infections
  18. Ulcerative colitis

If one has a TH1-dominated condition, the conditions that tend to prevail are:

  1. Diabetes type 1
  2. Multiple sclerosis
  3. Rheumatoid arthritis
  4. Uveitis
  5. Crohn’s disease
  6. Hashimoto’s disease
  7. Sjögren’s syndrome
  8. Psoriasis
  9. Sarcoidosis
  10. Chronic Lyme disease
  11. H. pylori infections
  12. E. histolytica

Glutrasol field observations show successes in both categories. For example, international travelers avoid flu and colds by consuming Glutrasol before a trip. In addition, Ramaekers Nutrition has success with psoriasis, Crohn’s disease, and H pylori infections (among a 20-year list of others). The biochemistry of transfer factor in Glutrasol contains cytokines from both TH1 and TH2 cells. It produces different cytokines in response to various situations.

Alvarez-Thull L, Kirkpatrick CH [11] note that “Transfer factor treatment selectively affects cytokine production in response to antigenic stimulation.”

Fabre RA et al. [12] (in a pulmonary tuberculosis study) showed that “the treatment with murine or human TF [transfer factor] restored the expression of TH-1 cytokines, TNFalpha and iNOS, provoking inhibition of bacterial proliferation and significant increase of DTH and survival.”

V. Adjusting to Change

Malaria is cited as a TH2-dominated condition. WHO [13] and PATH are working on a robust malaria vaccine.

CortControl acknowledges that parasites can mutate [14] and present a changing appearance to the immune system. This is one reason why malaria victims experience cyclical flare-ups. Antibody vaccines are specific and not designed to keep pace with mutations.

Maturation time for TH1 or TH2 cells is 10-14 days. In contrast, the biochemistry of transfer factor works on the innate immune system and responds within 24-48 hours. Transfer factor empowers the immune system to stay current with mutations.

CortControl predicts that the immediate benefits of combining Glutrasol with the malaria vaccine will be:

  1. Increasing vaccine efficiency and
  2. Minimizing relapse or re-infection.

VI. Rebalancing TH1 and TH2 Levels

Transfer factor can change TH1/TH2 predominance conditions within 48 hours [15].

This observation asks, “How can Transfer Factor change a predominantly TH-2 Immune System to a predominant TH-1 System so rapidly?”*

*The hypothesis of new TH1 cells was dismissed early because it takes 10-14 days to mature new TH1 cells.

The answer is “conversion by eomesodermin,” which was studied in 2003 [16].

  • Eomesodermin. Also known as T-box brain protein 2, it is a protein encoded by the EOMES gene in humans. The Eomesodermin/Tbr2 gene, EOMES, encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box.

In that study, already differentiated TH2 cells were converted into TH1 cells. Eomesodermin is a T-box transcription factor related to T-bet and is already characterized as a key regulator of mesodermal differentiation. Eomesodermin was up-regulated explicitly in activated CD8+ cells [one of the transfer factor’s actions].

The conversion of TH2 cells to TH1 cells is particularly relevant to viral vaccines and malaria, which tend to be TH2-dominated immune responses. In the opposite direction, the conversion of TH1 to TH2 is advantageous for Conditions Such as Rheumatoid arthritis or Crohn’s disease.

VII. Viruses, Bacteria, and Parasites

Web MD notes, “Transfer factors are used for infectious conditions in people with weak immune systems. These infectious conditions include bacteria or viruses in the bloodstream (septicemia), sinus infections, bronchitis, influenza, swine flu, the common cold, shingles, chickenpox, hepatitis B, fungal infections such as coccidioidomycosis, yeast infections (candidiasis), parasitic infections such as leishmaniasis and cryptosporidiosis, and leprosy.

Transfer factors are also used against infections caused by viruses such as cytomegalovirus (CMV) and Epstein-Barr virus, bacteria such as Mycobacterium tuberculosis, Mycobacterium fortuitum, and Mycobacterium avium, and yeast-like fungi such as Cryptococcus and Pneumocystis carinii.

The Glutrasol formulation dramatically lowered the mortality rate of parasite-infected livestock herds [9]. Simultaneously, weight gain improved.

CortControl does not believe that we “cured” the affected herds. Instead, we believe Glutrasol better staged the subject’s immune system to resist parasites and opportunistic infections.

This immune response has applications for countries where water-borne parasites negatively affect child development.

Stunted childhood growth is a significant global health issue. Low weight gain in livestock and stunted human growth are probably related.

VIII. Staging the Immune System

The response to vaccination depends on the recipient’s health. Vaccines work best for healthy people. Conversely, a person with a weakened immune system may not derive the full benefits from the calculated vaccine. This relationship is significant in less developed countries, where unsanitary conditions impact overall health.

Dr Mandal [17] notes, “This [a lower-than-expected vaccine response] could be due to various reasons. Sometimes, this is because the host’s immune system doesn’t respond adequately or at all. This could be in diseased persons with lowered immunity, e.g., in people with diabetes, those on steroids or other immunity-suppressing drugs, or those with HIV infection.

B Cell Activation

The non-development of immunity to disease could also be due to the host’s immune system not having a B cell capable of generating antibodies against the antigen or microbe, or the immune system may not be strong enough to fight off the infection.

Glutrasol. Formulated to narrow the health gap and make vaccine benefits accessible to a larger population.

IX. Adjuvant Application

Several articles suggest the use of the Transfer Factor as an adjuvant.

  • An adjuvant is a chemical substance added to some vaccines to help the body’s immune system respond more effectively to the vaccine’s antigens.

Schroder et al. [18] state, “This interspecies adjuvant effect was proportional to the dose of the ‘transfer-factor’ preparations administered, depended on the method of their preparation, and was expressed in the administration of the preparations simultaneously with the immunization.”

Wang et al. [19] state, “In conclusion, these results suggest that TF [transfer factor] possess better cellular immune-enhancing capability and would be exploited into an effective immune-adjuvant for inactivated vaccines.”

X. Dramatic Pictures of Results of Consuming Transfer Factor

The following images are two patient examples. We have an extensive database of animal results using our patented formulas.

Calf with Severe Warts

Before Transfer Factor Consumption

Before Transfer Factor Consumption. Cow with severe warts.

6 Months Later

After Transfer Factor Consumption

After Transfer Factor Consumption. Cow with severe warts.

Horse with Eye Cancer

Before Transfer Factor Consumption

Before Transfer Factor Consumption. Horse with eye cancer. Image one.

During Transfer Factor Consumption

During Transfer Factor Consumption. Horse with eye cancer. Image two.

After Transfer Factor Consumption

After Transfer Factor Consumption. Horse with eye cancer.

References

  1. Lawrence HS, Borkowsky W., “Transfer factor—current status and future prospects,” Biotherapy 1996;9(1-3):1-5. https://www.ncbi.nlm.nih.gov/pubmed/8993750
  2. www.linked2.info/dvm
  3. Mazaheri R, Hamblin AS, Zuckerman AJ., “Cell-mediated immunity: correlation of mixed-leucocyte-macrophage migration inhibition with delayed-type hypersensitivity after immunization and donor-specific transfer of cell migration inhibition by dialyzable leucocyte extract,” Cell Immunol. 1983 Nov;82(1):147-62. https://www.ncbi.nlm.nih.gov/pubmed/6196129
  4. Kirkpatrick CH, Rich RR, Smith TK., “Effect of transfer factor on lymphocyte function in anergic patients,” J Clin Invest, 1972 Nov;51(11):2948-58. https://www.ncbi.nlm.nih.gov/pubmed/5080419
  5. Salazar-Ramiro A, Hernández-Pedro NY, Rangel-Lopez E, Cruz VPD, Estrada-Parra S, et al., “Dialyzable Leukocyte Extract (Transfer Factor) as Adjuvant Immunotherapy in the Treatment of Cancer,” MOJ Auto Dis 1(1): 00003. DOI: 10.15406/mojad.2016.01.00003.
  6. Cortesini R1, LeMaoult J, Ciubotariu R, Cortesini NS., “CD8+CD28- T suppressor cells and the induction of antigen-specific, antigen-presenting cell-mediated suppression of Th reactivity”, Immunol Rev. 2001 Aug;182:201-6. https://www.ncbi.nlm.nih.gov/pubmed/11722635
  7. Filaci G. et al., “Nonantigen specific CD8+ T suppressor lymphocytes originate from CD8+CD28- T cells and inhibit both T-cell proliferation and CTL function”, Hum Immunol. 2004 Feb;65(2):142-56. https://www.ncbi.nlm.nih.gov/pubmed/14969769
  8. Salazar-Ramiro A, Hernández-Pedro NY, Rangel-Lopez E, Cruz VPD, Estrada-Parra S, et al., “Dialyzable Leukocyte Extract (Transfer Factor) as Adjuvant Immunotherapy in the Treatment of Cancer,” MOJ Auto Dis 1(1): 00003. DOI: 10.15406/mojad.2016.01.00003. http://medcraveonline.com/MOJAD/MOJAD-01-00003.php
  9. https://ramaekersnutrition.com/library/the-mechanism-of-transfer-factor/
  10. Kidd P., “Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease”, Altern Med Rev. 2003 Aug; 8(3):223-46. https://www.ncbi.nlm.nih.gov/pubmed/12946237
  11. Kirkpatrick CH, Rich RR, Smith TK., “Effect of transfer factor on lymphocyte function in anergic patients,” J Clin Invest, 1972 Nov;51(11):2948-58. https://www.ncbi.nlm.nih.gov/pubmed/5080419
  12. https://www.ncbi.nlm.nih.gov/pubmed/15086383
  13. http://www.who.int/mediacentre/factsheets/fs094/en/ “Malaria Fact sheet N 94”. WHO. March 2014.
  14. http://www.theexpandedheart.com/Transfer.html
  15. http://ramaekersnutrition.com/library/the-mechanism-of-transfer-factor/
  16. SCIENCE, p. 1041, Vol. 302, Nov. 2003. http://science.sciencemag.org/content/302/5647
  17. http://www.news-medical.net/health/Vaccine-Effectiveness.aspx
  18. https://www.ncbi.nlm.nih.gov/pubmed/419903
  19. www.ncbi.nlm.nih.gov/pubmed/22705080

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The Science Behind Glutrasol

The Science Behind Glutrasol.

How does Glutrasol work?

To improve overall health and integrated treatment efficacy, Glutrasol supports the immune system by employing three chemistries key to Glutrasol‘s science-based specialty supplement: transfer factor, beta-glucans, and lactic acid-generating bacteria.

Transfer Factor 

Transfer factor is commonly derived from colostrum, a cow’s first milk after calf delivery. This milk contains information in the form of small proteins (polypeptides) that transfer immunity from cow to calf or from cow to human.

In Glutrasol, the proteins are separated by molecular weight. Other sources of transfer factors include eggs, sheep, goats, and lysed cells. As various sources are mixed, the scope of immunity typically increases. If people take transfer factors daily, their immune capability—as measured by killer white blood cells—could increase by as much as 250%.

Proteins separated by molecular weight.

Proteins are separated by molecular weight.

Beta-Glucan

Beta-glucan stimulates the two principal parts of the body’s immune system: the innate and the acquired immune systems.

Innate immune systems

In the innate immune system, beta-glucan binds to macrophages, a type of white blood cell that detects bacteria, viruses, and other pathogens, thereby coordinating the body’s defenses against them. When activated by beta-glucan, macrophages have a greater ability to identify and destroy foreign intruders. After devouring pathogens through phagocytosis, macrophages communicate the presence of the intruder to the body’s other defenders. Research shows that macrophages fortified by beta-glucan can rally the body’s defenses.

Macrophage activation via cell surface receptor.

Macrophage activation via the cell surface receptor.

Acquired immune systems

After this, the acquired immune system joins the fight. With the information transmitted from the macrophages, the acquired immune system learns to manufacture other killer cells and blood factors designed to defend against a specific attack. These include B-cells, which produce antibodies. The antibodies, working in conjunction with the innate immune system, bind to and destroy foreign invaders, forming clusters. Macrophages then overwhelm these. This process is how the body eliminates infections and diseases.

Lactic Acid-Generating Bacteria

Lactic Acid-Generating Bacteria.

Lactic Acid-Generating Bacteria

Many assume that glucose is the primary energy source for living tissues; however, there are indications that neurons in the human brain preferentially metabolize lactate rather than glucose.

Digestive Health

Lactic acid-generating bacteria also have significant positive effects on digestive health. Foods such as cod liver oil and sauerkraut, for example, derive their benefit from lactic acid-generating bacteria. The liver, pancreas, and kidneys are less stressed when digestion is good.

The immune system is supported because beneficial lactic acid-generating bacteria displace pathogens in the digestive tract, restoring healthy mucus in the intestinal lining.

Supporting Immune Health

—Richard Bennet, Ph.D.

The Science Behind Glutrasol: An Integrative Approach to Supporting Immune Health

Glutrasol helps to support immune system health

The Challenge

The global need to address immunodeficiency disorders is real and immediate. Richard Bennet, Ph.D., states, “Our ability to create a really healthy immune system represents the greatest potential gains in health in the world.”

Immune System Health

The outcomes resulting from diminished immune system health are numerous and varied. Compromised immune health affects the ability to fight off pathogens, leaving at-risk populations, especially the elderly or those in developing countries, at a disadvantage in avoiding disease.

At-Risk Populations

Seniors

Many seniors are at risk of contracting disease due to physical limitations, existing health concerns, or nutritional deficits. Providing a robust immune health foundation can effectively arm seniors with a better ability to maintain good health and vitality.

Developing Countries

In many developing countries, vast numbers of at-risk populations arrive at support organizations with immune systems that are severely compromised, either from inadequate nutrition, poor sanitation, environmental stress, or aging. Poor sanitation, nutritional food, and environmental distress are common and systemically complex to overcome.

One solution to support these at-risk groups is to provide nutraceuticals or specialty supplements, such as Glutrasol, to help these populations improve their immune system health.

World Globe. Developing Countries.

Developing countries are located mainly in Africa, Asia, Latin America, and the Middle East.

Infectious disease epidemics cost the world US$60 billion each year. They match wars and natural disasters in their capacity to endanger lives, disrupt societies, and damage economies.

— Coalition for Epidemic Preparedness Innovations (CEPI)

The Science Behind Glutrasol: Immune-System Health and Antigen Exposure

Immune system health is an important factor in fighting disease

Fighting Disease

Immune system health is a crucial factor in combating disease. Dr. Ananya Mandal, MD, notes that “the reason for non-development of immunity to a disease could also be that the host’s immune system does not have a B cell capable of generating antibodies against the antigen or microbe, or the immune system may not be strong enough to fight off the infection.”

Kenneth L. Marcella, DVM, states, “It is the immune system, after all, which allows humans and animals to recognize and remember potentially harmful foreign substances such as bacteria and viruses. The immune system allows us to respond to these threatening invaders in our systems.”

CortControl’s Glutrasol helps build the immune system to respond better to antigenic exposure.

Maximizing Immunity and Extended Protection

Glutrasol is a nutraceutical specifically developed to support immune system health. When Glutrasol compounds were tested on cattle, cell-mediated immunity increased 4-5 times. Additionally, non-responsive populations to an antigenic stimulus without Glutrasol compounds developed a response when treated with Glutrasol compounds. Furthermore, animal testing demonstrated increased protection periods, rendering recipients less susceptible to additional health concerns.

Global healthcare workers care for vast populations in many developing countries.

Efficacy and extended protection periods affect logistics and economics. From a practical standpoint, reducing the frequency of interactions stretches the budget.

  • Fewer visits are required to achieve goals.
  • Delivery costs drop proportionately.
  • More time per visit becomes practical.
  • The need for follow-up treatments decreases.

Effective Delivery is Critical

“We should anticipate a growing frequency of infectious disease threats to global security,” says Peter Sands, Chair of the Commission on a Global Health Risk Framework for the Future. Maximizing the health of those in developing countries can help minimize the impacts of each new pandemic.

Treatments

Treatments must be stable and easy to manage in extreme climates and areas with significant sanitation challenges. Doses must be small, lightweight, and easy to administer and distribute.

Researchers

Researchers are looking at ways to enhance immune system health with easy-to-administer integrative solutions. Easy-to-transport specialty supplements are a promising approach. Glutrasol provides such a solution.

How Does Glutrasol Help Support Immune Health?

Glutrasol’s research shows:

  • An increased antibody titer for a subject by 4-5 times
  • Extended protection between vaccine booster treatments
  • Improved response to an antigenic stimulus
  • Provides ease of delivery in hard-to-reach populations
  • The product is stable in scorching climates

Additional positive, proven outcomes from animal research

  • Reduced stress
  • Increased food utilization or growth rate
  • Improved offspring mortality
  • Increased fertility

Supporting Fertility

The Science Behind Glutrasol: An Integrative Approach to Supporting Fertility

Glutrasol helps to support fertility

The Challenge

Many people consider the prospect of having children one of life’s great experiences. Sadly, though, according to the Mayo Clinic, between 10% and 15% of all couples of childbearing age have difficulty either conceiving or carrying a pregnancy to term. The health of both men and women contributes to this statistic.

Immunity vs. Fertility

Contributors to fertility support are numerous. Among these are a healthy immune system and balanced levels of cytokines.

The immune system and reproductive systems are interdependent. Reproductive immunology is a well-established field of medicine that studies interactions (or their absence) between the immune system and components related to the reproductive system.

Cytokines are critical components of the immune system.

They are small proteins that act as immunomodulatory agents, impacting the immune response. The body’s immune resources are naturally prioritized to address health threats first. As a lesser priority, fertility capacity is negatively affected when the body fails to fight pathogens, even at subclinical levels.

To learn more, see Cytokine Balance Supports Immune Health and Balanced Cytokines Aid Prevention.

Glutrasol Supporting Fertility.

Cytokine Balance

Dr. Marie-Pierre Piccinni, from the Institute of Internal Medicine and Immunallergology at the University of Florence, Italy, found that cytokine balance plays a crucial role in implantation and successful pregnancy (Piccinni et al., 1998). Cytokine balances further allow the survival of the fetus throughout gestation. (Piccinni and Romagnani, 1996).

Further, a clinical study performed on 100 healthy women showed that a low FAAH (fatty acid amide hydrolase) activity in lymphocytes correlated with spontaneous abortion. [Source: Mauro Maccarrone, Department of Experimental Medicine and Biochemical Sciences and † Division of Obstetrics and Gynecology, University of Rome Tor Vergata, Rome, Italy; and ‡ Fatebenefratelli Association for Research, San Giovanni Calibita Hospital, Rome, Italy]

The Science Behind Glutrasol: Fertility and Cytokine Balance

There are inflammatory and non-inflammatory cytokines

Women’s Fertility

The inflammatory-to-noninflammatory cytokine ratio is a known reliable indicator of women’s fertility. If the ratio is too high, conception is unlikely to occur. If the conception probability is more balanced, it is higher. Pathogens interact with the immune system to induce the production of inflammatory cytokines. In contrast, friendly bacteria (such as lactic acid bacteria) create non-inflammatory cytokines.

Inflammatory Immune Cells

Inflammatory immune cells are specifically drawn to the site of a viral infection. Once there, they produce their characteristic inflammatory cytokines. A robust immune system would soon rid the body of the virus, and the level of inflammatory cytokines would fall. A weak immune system won’t finish the job, and high inflammatory cytokines will persist, even though viral symptoms may not be obvious.

One crucial factor related to fertility is maintaining the proper balance of inflammatory and non-inflammatory cytokines.

Both Sexes Impacted

Cytokine balance can affect men and women differently.

A 2014 study published in the journal Seminars in Reproductive Medicine showed that inflammation can disrupt the balance of estrogen and progesterone, the two primary hormones involved in the menstrual cycle. When these two hormones are out of balance, it’s nearly impossible to get pregnant or carry a baby to full term.

Male fertility is also impacted. Anna Havrylyuk, Department of Clinical Immunology and Allergology, Danylo Halytsky Lviv National Medical University, Lviv, Ukraine, has noted that “Cytokines have been important mediators of immunity, and can be involved in numerous processes in the male genital tract, including acting as immunomodulatory elements within the male gonad.”

Stress, Immune Function, and Fertility

Stress affects immune function, and in turn, immune function impacts fertility.

Allen Morgan, MD, the director of the Shore Institute for Reproductive Medicine, says, “When stress-reduction techniques are employed, something happens in some women that allows them to get pregnant when they couldn’t get pregnant before.”

And, as Margareta D. Pisarska, MD, the co-director of the Center for Reproductive Medicine at the Cedars Sinai Medical Center in Los Angeles, has observed: “It’s becoming more and more important, in terms of what studies we do, to focus our efforts on the physiological effects of stress and how they may play a role in conception.”

The connection between immune function and stress is evident. When your body is stressed due to illness or emotional distress, it fights to get well. Reproduction is a lesser priority. At the University of California in San Diego, researchers found that highly stressed women ovulated 20% fewer eggs than women who experienced lower stress.

How Does Glutrasol Help Support Fertility?

Glutrasol strengthens the immune system with three active components: transfer factor, beta-glucans, and lactic acid-generating bacteria to support fertility. The combination contains and balances cytokines. Strengthened immunity leads to better health, and better health supports fertility.

Glutrasol offers a personalized, all-natural alternative for enhancing fertility.

Glutrasol is a cost-effective fertility aid that is less costly, less invasive, and more effective than other claimed fertility aids. It can stand alone or augment an integrated program, providing a reliable and affordable solution. It offers a personalized, all-natural alternative for enhancing fertility.

To learn more, see Specialty Nutraceuticals and Fertility.

Supporting Endurance Athletic Performance

The Science Behind Glutrasol: An Integrative Approach to Supporting Endurance Athletic Performance

Glutrasol helps support endurance athletes

The Challenge

Endurance athletes push through countless limits to compete in their sports. Most are rigorous and supremely disciplined regarding their nutrition, sleep, and training methods. However, many athletes may overlook immune system support as an integral component of their training, performance, and recovery regimen.

“When pursuing a more demanding training regimen, it’s important that the exerciser optimize immune responses,” writes Roy J. Shephard, M.D. Lond, PhD DPE, and Pang N. Shek, PhD, of the University of Toronto School of Physical and Health Education.

Optimal Performance

The power of immune support is often misunderstood. Our immune system is typically viewed as a matter of wellness versus illness, rather than optimal performance. But it’s fundamental to both and is found to be compromised in many endurance athletes.

In fact, in the British Journal of Sports Medicine, Bente Klarlund Pedersen and Anders Dyhr Toft, from The Copenhagen Muscle Research Centre and Department of Infectious Diseases, note that “Moderate exercise across the lifespan seems to increase resistance to upper respiratory tract infections, whereas repeated strenuous exercise suppresses immune function.”

Endurance Athletic Performance.

How the Immune System Affects Athletic Performance

The immune system is directly connected to the central nervous system via immune-system proteins (technically called “cytokines”). These proteins facilitate the release of regulatory hormones, which mediate various physiological functions that occur on a daily basis. We’ll examine some of the impacts of immune system imbalance regarding their implications for training, performance, and recovery.

The Science Behind Glutrasol: Optimize Immune Responses

Demanding training regimens require a fast recovery

Before an Event

The value of a calm mind and sound sleep is well understood. Before an event, mental stress depletes energy reserves and reduces sleep quality.

Pre-event stress is cited as a negative factor in roughly 60% of competitors. Cortisol is the primary stress hormone. Mental stress effectively triggers the hypothalamus–pituitary–adrenal axis to produce cortisol. This sequence applies to all mammals.

Fortunately, the hypothalamic gland also houses the cortisol control loop. With the proper immune-protein stimulus from products like Glutrasol, cortisol production declines, sleep improves, and less vital energy is wasted.

During the Event

Changes in blood flow, increased cardiac output, heat dissipation, hydration status, and sweat production are critical factors during high-intensity exercise. These operating set points interact with each other and with the environment. Hormones (released in response to immune-protein permeation to the brain during exertion) affect the range of operation. Maintaining these factors within a normal range is crucial for optimal performance.

Shephard and Shek further suggest that “participation in a major marathon event increased the odds of infection almost sixfold relative to the experience of other runners who did not participate.”

Performance and Recovery

Electrolyte losses are controlled by hormonal thermal regulation. Imbalances among water, sodium, potassium, and chloride limit performance. Willpower can’t substitute for electrolyte imbalance.

Likewise, elevated cortisol and catecholamine hormone levels, which increase during moderate and strenuous exercise, can negatively impact performance. Supporting healthy cortisol levels by balancing cytokine proteins associated with the immune system can have a positive effect.

As Katsuhiko Suzuki, Faculty of Sport Sciences, Waseda University, noted, “Cytokines mediate exercise-induced inflammation, immunosuppression, and energy metabolism.” Glutrasol enhances cytokine balance to support peak performance and recovery.

To learn more, see Cytokine Balance Supports Immune Health and Balanced Cytokines Aid Prevention.

Recovery and Overtraining Syndrome (OTS)

Intense exercise stresses the body, and a fast recovery is necessary and a priority. We understand the importance of your recovery in maintaining peak performance.

“One of the major components of all training programs is the principle of progressive overload, implying working beyond a comfortable level,” write Joanna Ostapiuk-Karolczuk, Anna Kasperska, and Ryszard Botwina, of the University School of Physical Education, Poznan, Poland. “However, there is a fine line between improved performance and deterioration.”

Rebalance Faster

Without adequate recovery, an athlete is at risk of developing overtraining syndrome. Symptoms include respiratory infections, decreased serum testosterone, amenorrhea, impaired cognitive abilities, lack of concentration, and depression.

Recovery typically begins by replenishing electrolytes (such as sodium, potassium, and chloride) and water. At the finish line, everyone replenishes.

But that’s just the beginning. Recovery is primarily based on rebalancing the immune proteins, which in turn balance the body’s hormones and stabilize its homeostatic points. The body returns to its balanced condition, and Glutrasol enhances this balancing process, allowing you to rebalance faster and be less susceptible to illness or overtraining injuries.

Support Before, During, and After Competition:

Glutrasol will help you manage:

  • Optimal health during training
  • Stress before your endurance event
  • Optimal performance levels during your event
  • Increased recovery levels after your event

Glutrasol is a reliable choice for recovery enhancement. It is 100% natural and contains no substances banned by the World Anti-Doping Agency (WADA). This natural composition reassures you that you’re fueling your body with the best without any concerns about doping.

To learn more, see Improve Your Athletic Ability.

Over 35 Years of Successful Treatments

Glutrasol testing has been conducted almost exclusively with animals at our parent company, Ramaekers Nutrition. For more than 50 years, veterinarians have prescribed many of the same compounds in Glutrasol to treat various diseases with considerable success.

Animal Testing

The animal testing range includes hundreds of thousands of cattle, pigs, horses, and other livestock, and the results have often been dramatic. Fertility in cattle, for example, has increased, in some cases, by more than 70%. In vaccine immuno-enhancement, antibody titers showed improvements of more than 360% at 21 days.

What is a Nutraceutical?

As a nutraceutical, Glutrasol is regulated by the FDA as a dietary supplement under the authority of the Federal Food, Drug, and Cosmetic Act. Unlike drugs, supplements are not intended to treat, diagnose, prevent, or cure diseases. A nutraceutical is a specialty supplement containing active constituents from foods, herbs, natural compounds, and other botanicals. Nutraceuticals offer pharmacological benefits and are specifically designed to support specific structural and functional applications in the body.

For more information on specialty supplements, please visit our pages on Strengthen Your Immune Defenses, Immune-Building Supplements, and Specialty Nutraceuticals.

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Chewing and Itching Symptoms Improved

Tango. Featured Pet using Vet Immune Professional Tabs for arthritis, chewing, and itching.

Tango got his start in life as a street dog in Buenos Aires, Argentina.

He was hit by a car as a young pup- resulting in him having a crushed elbow, which healed painfully in the streets, resulting in him essentially being a 3.5-legged dog. His front elbow is held together with essentially scar tissue and bone fused together when it healed without medical intervention.

We brought Tango home to California with us when we were there on vacation. He’s the best dog, and we want the best for him.

Tango is eight now and has arthritis. He started to get fatty lumps and was very itchy. He had a lump on his front leg, and we had it surgically removed. Once it healed, he would chew this heck out of it- and it was constantly an open sore and a battle. Nothing medical we tried worked. We tried everything. We would heal the open sore on his leg by blocking him from chewing on it using an infant sock and horse tape, and it would heal to the point fur grew back (6-12 weeks). When we would take off the sock, he would go right back to chewing it and down to tissue in a minute.

Chewing and Itching Symptoms Improved

We started him on the Vet Immune Professional Tabs, which were given in meatballs. Two weeks later, the small fatty lumps on his back had gone down, and his sock bandage came off his leg. Miraculously, he hasn’t touched that leg at all – now it’s been 3 weeks of him not chewing or itching. We don’t put the sock on anymore. His coat looks amazing, and he is relaxed and happy. I can’t thank Dr. Raemaekers enough!

Professional Formula for Dogs and Cats

Vet Immune Professional Products are our professional veterinary immune products for dogs and cats. The powder and tabs are formulated for therapeutic use in animals as an adjunct to chemotherapy, surgery, or radiation. Incorporate the immune powder and tabs into any holistic or Western medicine therapy plan.

The owner’s feedback is excellent when using our Vet Immune Professional Products for cancer patients. This formula offers pet owners a viable alternative for therapy when chemo, surgery, or radiation is not an option. It also provides excellent nutritional and patient support when used adjunctively with traditional cancer therapy protocols.

Dr. Ramaekers’ Vet Immune Professional Products addresses several areas of need in these critically ill patients.

Applications

  • Auto-Immune Disorders
  • Dermatitis~ Bacterial & Fungal
  • Allergies-respiratory & skin
  • Bone Marrow Dysfunction/Pancytopenia/
  • Lymphocytic Leukemia
  • Vaccine Response Enhancement
  • Improved Athletic Performance & Endurance
  • Anti-Viral Effects
  • Stress-induced diarrhea
  • Degenerative Joint Disease/Arthritis
  • Tumor Size Reduction
  • Thyroid Conditions
  • Canine Cancers~ Benign & Malignant

The patented Transfer Factor and Medicinal Mushroom blend greatly improved immune function to help battle cancer on a cellular level. The medicinal mushrooms offer anti-angiogenic properties to help starve the tumor of its essential blood supply, improving cellular energy production(ATP) and lung oxygen absorption.