Transfer factor: Long-awaited next step in immunotherapy

Updated: Feb 19, 2024
Original: Feb 01, 2003

By Kenneth Marcella, DVM


Proposed advances

Immunotherapy was predicted to be one of the most rapidly expanding areas of medical science in this decade.

Proposed advances in our ability to manipulate the protection offered by the body's own immune system were going to make humans and animals far healthier and were promising to increase both the length and quality of life.

Immune agents were going to be our new defenses against those microorganisms that no longer responded to antibiotics, and diseases from allergies to cancer were going to be subdued by this new field.

Transfer Factor: The long-awaited next step in immunotherapy

To date, however, those advances have been slow in coming. We have been unable to manipulate the body's defenses as planned, and we have few effective immune stimulants.

Positive research data has been piling up concerning the most promising immune agent in years, though, and immunologists may be finally making good on their earlier predictions.

Transfer factor, as this new immune compound is being called, may be the long-awaited "next step," and it may be everything that was promised.

Richard Bennett, Ph.D., an infectious disease immunologist, writes, "It is our ability to create a really healthy immune system that I think represents the greatest potential gains in health in the world."

After all, the immune system allows humans and animals to recognize and remember potentially harmful foreign substances such as bacteria and viruses. The immune system allows us to then respond to these threatening invaders in our systems.

Devastatingly familiar

The consequences of suppressed or damaged immune system conditions are devastatingly familiar to veterinarians.

Arab foals with combined immunodeficiency complex and older horses with chronic laminitis due to Cushing's disease-related effects are but two such examples. Respiratory problems in young foals, allergies, skin infections, and hoof wall diseases are other problems that can also be related to immune system dysfunction.

A new agent that would vastly improve horses' immune function would warrant some attention. Transfer factor promises to be this new agent. It is a colostrum component produced to be used as a powder added to the diet.

Structure and function

To understand what this colostral derivative may potentially mean to veterinarians and horses, it is necessary to briefly review the structure and function of the immune system.

The body has two principal immune defense systems: humoral and cellular. B-lymphocytes in the liver, spleen, lymph nodes, and bone marrow produce plasma cells that, in turn, produce antibodies in the gamma globulin fraction. These immunoglobulins can potentially recognize huge numbers of antigens. This is the basis of humoral immunity.

Humoral immunoglobulins are primarily designed to fight bacterial infections. Lymphocytes that populate the thymus become responsible for cellular immunity. These cells produce structures called lymphokines that mediate delayed hypersensitivity or allergic reactions. They are responsible for rejecting transferred foreign tissue and for recognizing and rejecting tumor cells.

The cellular immunity system is responsible for defense against infections due to viruses, fungi, and some types of bacteria and cancers. Transfer factor stimulates both portions of the immune system.

In the beginning

In 1949, Dr. H. Sherwood Lawrence, a researcher working on tuberculosis, found that he could transfer immunity between patients using fractionated white blood cells. The key ingredient was a part of the lymphocyte cell, and Lawrence called this component "transfer factor."

This discovery was not actively pursued for nearly 30 years until the late '80s. At that time, colostrum and milk were discovered to contain significant amounts of transfer factor. The exact mechanism of action of the transfer factor has never been determined, but it is now known that the transfer factor is lymphokine. The two most notable lymphokines are interferon and interleukins.

These lymphokines are protein messengers thought to be released by antigen-sensitized lymphocytes. They play a role in macrophage activation, lymphocyte transformation (the process of precursor cells becoming B and T cells), and cell-mediated immunity. Transfer factor is one of the most potent messengers and has three distinct effects on the immune system.

Recognizes antigens

Transfer Factor: The long-awaited next step in immunotherapy helps the body recognize antigens.

Dr. M. Metz, a veterinarian,  points out that 200 mg (one capsule) of transfer factor has the potential to recognize at least 100,000 pathogens. Metz adds that not only can transfer factor be specific for an individual antigen that a lymphocyte is exposed to but "transfer factor can also stimulate a multivalent response."

In this type of response, the transfer factor activates lymphocytes to several strains of an organism.

"This is the really exciting part of the transfer factor from a practicing veterinary standpoint," says Metz.

Research has found that exposing cattle to various bacteria and viruses can produce a transfer factor that will stimulate immunity to other related strains of bacteria and viruses that are much more pathogenic to other species.

"The other really exciting aspect of transfer factor," says Metz, "is the time sequence."

Most types of delayed hypersensitivity immunity, such as that seen with vaccine use, take 10 to 14 days to develop. Metz says the transfer factor activates that same immunity in 24 hours!

Natural killer cells

Transfer factor is also a natural killer cell inductor. These non-specific attack cells seek out and destroy infected or malignant cells and cells infected by viruses.

Transfer factor increases natural killer cell activity five times over normal rates, and it is non-species specific. This aspect of the transfer factor is believed to be related to the significant improvements seen in certain cancer patients who have taken this product. Multiple sclerosis patients have also shown improvements.

The transfer factor in cats, dogs, horses, cows, and humans is structurally and functionally identical. This has helped in producing this product since cows can produce large quantities of colostrum that is then used to extract transfer factors.

Suppresses (down-regulation) immune function

Transfer Factor: The long-awaited next step in immunotherapy also suppresses immune function.

It is paradoxical that the same product can stimulate and suppress immune function, but transfer factor function depends on the specific antigens and the immune response status. Transfer factor can stimulate the release of T suppressor cells when "down" regulation is necessary due to overactivity. Autoimmune diseases, chronic obstructive pulmonary disease (COPD), and allergic reactions are situations where the body's own immune response has over-responded to antigenic stimulation. The transfer factor works in these situations because it can slow down this overactive response.

Obvious advantages

While discussions of the immune system tend to be fairly technical, the practical advantages of a potent new immune-stimulating treatment are obvious.

The ability to stimulate the horse's body to attack and destroy bacteria and viruses will reduce the amount and types of antibiotics that may need to be used by veterinarians. It is important to try to retain those antibiotics available to veterinarians and to use them to maintain their effectiveness for as long as possible.

If veterinarians can stimulate a better immune response to respiratory bacteria, skin pathogens, and various viruses, then the need to use antibiotics is lessened. If the transfer factor can produce such boosts in immunity in 24 hours, then the potential for use as a pre-travel protectant or a post-exposure treatment is tremendous.

Horses suffering from other diseases, such as Cushing's disease, laminitis, colitis, cancers ranging from sarcoids to melanomas, and reproductive conditions such as chronic metritis, may all benefit from transfer factor use. This product may indeed be the long-awaited next step, and the field of immunotherapy may finally fulfill its promise.