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Immune Modulating Supplements

Immune Modulating Supplements.

Ramaekers Nutrition Immune System Enhancement

Priming the immune system to respond appropriately to natural infection and antigens from vaccines is what the Ramaekers Nutrition Immune Modulating supplements are indicated for. Our studies in several species, found under News & Articles, reveal how vaccines given along with our supplements induce a quicker, higher, and more long-lasting antibody titer.

Immune modulation is a therapy concept that encourages a more balanced immune response in the body. It up-regulates the immune cells as needed and, just as important, down-regulates the immune response when needed. The Innate Intelligence of the body strives for this balance at all times. Our unique combination of ingredients allows this to happen without side effects.

Immune Modulating Supplements

One of the main indications of our immune supplements is that they allow for fewer vaccines overall. Yet provide the opportunity for more long-lasting protection. Immunotherapy can also be used to enhance the immune response to vaccines and natural infections. This approach particularly targets the 10% to 20% of the population identified as poor responders. That is to say, those individuals who fail to produce adequate levels of protective antibodies. Our studies found in News & Articles demonstrate that both of these actions do happen.

Also interesting is that when taking these types of immune active ingredients, we don’t observe clinically any increased allergies or adverse reactions in either healthy or sick patients. These products are so safe that they are given to newborns of all domesticated species.

So the message is, to improve the response to necessary vaccines, establish higher levels and more long-lasting levels of protection, need vaccine updates less often, and improve protection against and response to natural infection, it is advised to use Ramaekers Immune Formulas, available in non-ruminating and ruminating forms, see bovine products, and other livestock products.

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Introduction to Livestock Products

Introduction to Livestock Products.

Ramaekers Nutrition

Written by: Dr. Bob McClung

Introduction to Livestock Products: Immunotherapy

Discover the groundbreaking advancements in cattle technology through Ramaekers Nutrition’s innovative livestock products. Explore the transformative potential of immunotherapy in enhancing cattle health and productivity.

From time to time, an advancement or technology emerges that alters our perspective on a problem. In the cattle industry, this technology is known as immunotherapy. Immunotherapy is a relatively new and rapidly developing field in both human and veterinary medicine. This science enables us to educate the host’s immune system, aiding in the fight against viral and bacterial pathogens. The new technology is both financially rewarding and reasonable to utilize.

Despite our considerable knowledge of antibiotic therapeutic agents and targeted vaccination programs, it is acknowledged that we still have “disease wrecks.” An internationally patented advancement developed by Dr. Joe Ramaekers, Immune Primer, is available in both non-ruminating and ruminating forms, as seen in bovine products and other livestock products. When used in conjunction with sound husbandry and vaccination protocols, it enhances health and profit margins in nearly all cattle operations. In the last eight years, studies that have been done in dairy cows, dairy heifers, bull calf rearing, veal operations, cow-calf, goat, sheep enterprises back-grounding operations, and feedlot businesses have shown Immune Primer markedly reduces morbidity (sickness), mortality (death loss), improves performance and profit margins.

Introduction to Livestock Products: Immune Primers

When added adjunctively to sound management practice, Adult Immune Primer or Newborn Immune Primer has increased margins because improved health results in better performance. Savings from decreased illness, reduced antibiotic use, lower labor costs to treat cattle, more effective antibiotic responses, increased gain rates, and shorter feed times make the Immune Primer formulas even more critical in times of high feed costs for producers. A tremendous reduction in illness and death loss also provides income that was previously unavailable to the producer. As a practicing veterinarian who has used these products on my own cattle and sheep, as well as in my clients’ agribusinesses, with excellent results for 10 years, I am very pleased with these products. “I strongly feel these products have the greatest potential for improved profit of any new product introduced into animal production in the last 40 years.”

Introduction to Livestock Products: Method of Action

Immune Primer’s patented technologies utilize the top chemical messengers of the immune system to convert slowly reactive immune systems into highly responsive systems. These messengers are highly specific to the variety of microbial agents they are coded for and produced to target. The Immune Primer molecules educate the “natural killer cells” to recognize these pathogens and initiate a wide variety of cytokines (chemical messengers) and cellular responses that control the activity of the immune system. It, in fact, increases the immune response by over 400% above baseline. When used appropriately, these responses help prevent damage from bacterial, viral, and fungal agents and enhance the response to antibiotics and vaccines. This is a valuable adjunct to the management protocols currently in place. These ingredients are derived from natural products, a plus in marketing “all-natural” animal products.

Introduction to Livestock Products

Each category of cattle enterprise has its own set of disease problems. For example:

DAIRY COWS– transition cow problems

  • mastitis problems
  • breeding problems, reproductive efficiency
  • high somatic cell problems
  • calf problems

CALF REARERS

  • respiratory disease
  • scour problems~ viral, bacterial, protozoan

STOCKER-FEEDER

COW-CALF

  • breeding efficiency
  • increased conception rate
  • calf health problems
  • ET production enhancement increased # of eggs

SMALL RUMINANTS

  • newborn health, adjunctive treatment, CL prevention
  • improved conception, egg, and semen quality

All of the above areas have been or are being investigated. In all cases, strengthening the immune system has shown significant benefits for the producer in terms of production.

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Enhancing Embryo Quality

Enhancing Embryo Quality.

Embryo Quality Characteristics with Superovulated Cows Treatment with Nutrition

Horizons Nutrition Factor Immune Product (NHNFI)
G.H.L. Marquezinia, V.R.G. Mercadantea, M.M. Wardb, A.R. Spellc, J. Carterc, N. Paton, G. C. Lamba

  • North Florida Research and Education Center, University of Florida, Marianna, FL;
  • Nutrition Horizons, Lewisburg, OH;
  • Applied Reproduction Resources, Daphne, AL

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Chuteside Manner

Chuteside Manner.

Ramaekers Nutrition Thoughts: Securing the health of Dairy Steers

BY PATTI WILSON

We’ve all seen them. Many of us have fed them, and a few of us have had one in the deep freeze. Dairy steers make up nearly 20% of all fed cattle.

The sale of newborn bull calves may make up only one to two percent of gross sales from dairies. Until recently, there has been little incentive to give them the same care as their heifer mates. High labor costs and time restrictions on large dairies generally have a negative impact on the initial care of dairy bull calves. This is directly translated into inadequate or untimely administration of colostrum after birth. It sets up the calves for a lifetime of greater disease risk, lower growth rates, and unthriftiness.

Given today’s price of cattle, the shortage of numbers, and increased feedlot space, dairy bull calves are gaining importance in the beef industry. This fact alone should prompt dairies to administer first-class care to their bull calves. Calves that, in the past, may have only brought $5 per head may now be worth up to $500 off the farm. Compared to beef calves, dairy bull calves are at higher risk of illness due to how they are managed and raised.

Where does it start: Chuteside Manner

A dairy heifer calf is the princess of the barn. She is administered measured amounts of high-quality colostrum (tested with a colostrometer). She receives these two to three times prior to being moved out of the calving area. A general recommendation for administering colostrum is four quarts of high-quality product at birth. Followed by two quarts at 10 to 12 hours. Some dairies may even feed three times. Bull calves, however, are treated a bit differently. Being a by-product, many may get only one feeding, and some may get none. Many large dairies have calves picked up by “calf jockeys” on Monday, Wednesday, and Friday. And they often spend a week on the road. They are trailered to calf ranches where they are raised in large groups until they weigh 300 to 350 pounds. At that point, backgrounding lots purchase the calves, and they are moved out.

On a seasonal basis, morbidity on these young calves can reach 15 to 30 percent, and mortality 5 to 15 percent without our health program. Early pulls and death loss due to compromised immune systems are more measurable than events happening later in the lives of calves. A common problem, susceptibility to Mycoplasma pneumonia, can lead to other diseases. Eventually, the value of the drop at harvest from Holsteins is reduced by abscesses on the liver, lungs, and kidneys. Mycoplasma almost guarantees an abscessed liver, resulting in lowered grade percentages. Inadequate immunity affects every factor determining profitability.

What to do: Chuteside Manner

For folks feeding Holsteins, good intervention lies in using transfer factors and probiotics found in the Ramaekers Immune Primer Formulas. Joe Ramaekers, DVM, is a veterinarian from Santa Cruz, California. He is a lifelong student of immunology and is frequently called to consult with livestock producers of all species regarding communicable diseases. Ramaekers is conducting real-world tests and has developed Immune Primer Formulas which can be administered to large groups of cattle, fed to just a few, or even drenched in young stock. It is used to boost the immune system’s performance in healthy and compromised animals. He has long believed in effective preventative medicine using his patented Immune Primer for at-risk or stressed patients.

Cull Rates Cut to less than 1%

Stressed calves arriving from lengthy trips to calf ranches may be dosed with the Immune Primer Formulas on days one, two, and twelve, and spot treated with penicillin G as needed. Cheaper antibiotics appear to have enhanced effectiveness when used in combination with his Immune Primer Formulas. At one ranch, cull rates on calves under Dr. Ramaekers’ care have been cut to less than 1%, and groups of calves “even up” as they stay on the ranch.

For older preconditioned dairy calves, there is the Adult Stress Premix. This formula is indicated for use during stress windows such as transition, weaning, and transport.

Finished dairy steers when managed with Dr. Ramaekers’ immune conditioning program consistently attain improved carcass quality and reduced carcass discounts, resulting in higher profitability for the producer.

Average Return of $10 for Every Dollar Invested

Ramaekers’ hope is that the Adult Immune Primer Formula and Adult Stress Premix can be used in all-natural pens of cattle, replacing implants, hormone therapy, or other regulatory feed additives that may cause side effects such as lowering grade or potential toxicity. His goal is to return at least ten dollars for every dollar invested in his product. His historical data collected on almost 1 million head of cattle over 13 years shows an average return of $10 for every dollar invested.

With new antibiotic regulations coming down the pike, Ramaekers sees an increasing need to turn to a “prophylactic program”. A program that affords 24-hour protection and Primes the animal’s immune system for life. The current political climate is demanding the minimization of antibiotics. It is inconvenient and, to many of us in the livestock industry, unnecessary because we use our medications judiciously according to the label guidelines. The future may demand that we rely more heavily on the use of immune science to raise our production levels. Immune system priming will also help raise the effectiveness of all health products, including vaccines and wormers, and extend the life of Western medicine therapeutics. The use of non-prescription feed additives will end in 2016. Ramaekers Nutrition is being proactive in a market that is demanding an antibiotic and hormone-free product.

RESEARCH: CHUTESIDE MANNER

BOVINE VACCINE TITER ENHANCEMENT OCTOBER 2009
WILLOW CREEK FARMS, TIFFIN, OHIO

KEY POINTS: CHUTESIDE MANNER

  • COMPARISON BETWEEN IMMUNE PRIMER & PHASED RELEASE IMMUNE PRIMER
  • 320% TO 500% INCREASED VACCINE TITERS

In October of 2009, 45 steers from Zanesville, Ohio, were delivered to Willow Creek Farms in Tiffin, Ohio, owned by Dr. Robert McClung.

The steers were gate-cut into three groups:

Twenty heads were tagged with ODD numbers to receive the Adult Immune Primer, twenty heads were tagged with EVEN numbers to receive the Adult Immune Primer Sustained Release with Minerals, and five tagged controls received placebos.

The Adult Immune Primer group got the product on days 1, 2 & 12. The Adult Immune Primer Sustained Release with Minerals group got the product on days 1 &12. The controls were given placebos on days 1, 2 & 12.

On day 1, all cattle received the same worming and vaccine protocols. In addition, all cattle received a porcine, slow-release parvovirus and 5-way leptospirosis vaccine by Solid Tech Bacterin.

All cattle were bled on day 0 for baseline titers for porcine parvovirus and leptospirosis.

On day 12, all cattle received standard vaccine boosters, and the study groups received their second dose of Adult Immune Primer.

On days 21 and 42, all cattle were bled and weighed.

Observations on Chuteside Manner by Dr. McClung:

By the second day, ALL of the Treated calves suddenly stopped bawling and were feeding. On Days 3 & 4, compared to the controls, all the treated cattle had full bellies and appeared much more active.

On day 10, it was observed that some of the groups were visibly depressed and starting to show some respiratory signs. By day 12, 8 of the Adult Immune Primer group and 3 of the Adult Immune Primer Sustained Release with Minerals group had respiratory signs.

On day 16, Dr. McClung decided to mass treat the Adult Immune Primer group with antibiotics and 2 of the Adult Immune Primer Sustained Release with Minerals group.

On day 21, Dr. McClung repeated the Adult Immune Primer group’s antibiotics and re-bled all cattle in the study. After suspecting a vaccine failure and consulting with the manufacturer, Dr. McClung sent in titers for IBR, PI3, BVD, and BRSV. The manufacturer also suspected a vaccine failure or virus mutations. This was the first time in 5 years that Dr. McClung had problems with immune supplementation and vaccine response.

On day 42, all cattle were re-bled and weighed.

SUMMARY: Chuteside Manner

  • Essentially all cattle in the study had zero starting titers for the swine vaccines.
  • Both viral and bacterial components of the vaccines responded very strongly to Natural Immune Supplementation. And ranging from a 320% to 500% increase in titers.
  • Also discovered was a delayed loss of vaccine immunity, or in other words, a Prolonged Duration of Immunity.
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Calf Sickness Can Cost

Calf Sickness can Cost.

Although this article is dated, it demonstrates the hidden costs of calf illness and how illness early in life prevents maximum performance and limits complete genetic expression.  Using our bovine products from day one will help maximize health, lower drug and labor costs, improve feed efficiency, enhance genetic expression,  improve carcass quality, and increase profits.

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Reproduction Fertility in Cows

Reproduction Fertility in Cows.

Show Cattle Reproduction Natural Immunotherapy

Reproduction Fertility in Cows: Case Results Chart. Our patented products stand at the forefront of immune system enhancement for Bovine. Our products for the bovine species are safe, healthy, effective, natural, and environmentally friendly.

Patented formulas provide technology and opportunity.

Our patented formulas provide the technology and opportunity for newborn and adult ruminants to absorb the equivalent immune information and education found in six gallons of colostrum in an easy-to-deliver form. Our field veterinarians use these products as adjunctive and preventative therapy in treatment programs with or without antibiotics. The key to this approach is modifying the animal’s response to stress (cortisol production) and maintaining a highly functional and vigilant immune system.

Reduce Cortisol

The key to this approach is to modify the animals’ normal response to stress (increased cortisol production), thus maintaining a highly functional and vigilant immune system. Our studies demonstrate that we can reduce excessive cortisol release (by 42%) associated with stress using a safe and economical product, conveniently delivered at all stages of production.

Integrating Supplements with a Herd Health Program

Natural Immunotherapy

We strongly advise incorporating these natural supplements, Newborn Immune Primer and Adult Immune Primer, into a proven herd health program that includes appropriate vaccine protocols, rations, and, most importantly, mineral and trace mineral supplements. We have found in our case studies that by integrating our supplements with a herd health program, we have seen significant results with the following:

  • BVD (Bovine Viral Diarrhea)
  • BRD (Bovine Respiratory Disease)
  • Pneumonia
  • Shipping Fever
  • Stocker and Feeder stress
  • And many other health issues

Health and Vigor

Trials repeatedly have shown an improvement in Health and vigor that translates to

  • Decreased sickness to below 6%
  • Decreased death loss to .2-1%
  • Increase in weight gain and feed conversion
  • Decreased days on feed
  • Increased performance ↑efficiency with a 15% improvement
  • Increased yield ↑2-3%
  • Increased Prime and Choice grades
  • For “All Naturals,” Increased Health results in an increased number of cattle on the program to receive the all-natural bonus at harvest.

Birth to Harvest

In the “all-natural” business of buying single-source, preconditioned cattle, our formulas help control Bovine Respiratory Disease (BRD). Since we know that 46% of healthy cattle harbor Mycoplasma in their respiratory tracts, as identified via PCR testing, prevention is crucial to enhancing immune function before the onset of stress and disease. For optimal results, it is essential to enroll all cattle in the program to maintain their health from birth to harvest.

Reproduction Fertility in Cows Results Chart

Reproduction Fertility in Cows chart.

Don’t take our word for it…

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Natural Beef Feedlot

Natural Beef Feedlot.

July 2004, Minden, Nebraska

KEY POINTS:

  • ZERO% DEATH LOSS
  • .004% Treats vs. Historically having 13% Treats
  • OMRI Listed Product

This feedlot specializes in “natural beef,” feeding 9,000 heads annually for a major distributor. The study started with 750 heads of 5 & 6 weights, not pre-conditioned, traveling 600 to 2000 miles from California, Texas, and Arkansas.

Historically, the cattle are fed grass hay on day one and processed with deworming and vaccines on day two. Revaccination occurs in 12 days. Standard processing protocols over the past nine years have yielded mortality rates of 1 to 1.5% and pull rates of 13%.

This study started on July 24, 2004, with all 750 incoming heads receiving two (2) one-ounce gel caps on day one of Ramaekers IMMUNE PRIMER. On day two, a pelletized starter ration with one ounce of IMMUNE PRIMER per 5-lb ration was started daily for three days. All cattle consumed approximately 5#’s of ration per day.

At the end of the study, death loss was zero, and only three were treated once for respiratory symptoms.

Natural Beef Feedlot Summary:

  • Manage Stress By Starting Early Immune Supplementation with IMMUNE PRIMER.
  • Invest in Health EARLY to prevent the cost of disease management.

Learn More about our Bovine Products

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Mastitis Study

Mastitis Study Dairy Cattle.

Dairy Study: Somatic Cell Reduction

MASTITIS STUDY KEY POINTS:

  • Somatic Cell Count Reduction: 59.7%
  • OMRI Listed Product

A study on somatic cell counts was conducted involving 26 cows with chronically high somatic cell counts. Thirteen cows were randomly assigned to the study group, while the other thirteen formed the control group. Initial testing on August 21, 2003, revealed that the control group had an average somatic cell count of 1,854,811, while the treatment group had an average count of 2,374,000.

During the 60-day study period, the control group received standard mastitis treatment protocols. In contrast, the cows in the study group were given one ounce of Ramaekers Livestock Stress Stable daily for three days, followed by three days off, for a total of three cycles (nine treatments).

Somatic cell count testing was repeated on September 18, 2003. The control group experienced a 10.5% increase in somatic cell counts, whereas the study group saw a significant decrease of 59.7%. This results in a 70.2% improvement in somatic cell counts when compared to the control group.

Of the treated cows, nine returned to production, while only one cow from the control group recovered after receiving heavy medication.

Summary: Mastitis Study

Mastitis Study. Somatic Cell Counts.

Using an OMRI-listed immune support product can be more effective than drug therapy for mastitis. Ideally, immune support products like LSSS should be used as preventative measures. Additionally, there are no withdrawal times associated with LSSS.


Learn More about our Bovine Products

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Improved Embryo Quality and Quantity

Improved Embryo Quality and Quantity.

Improved Embryo Quality and Quantity

Ken and Julie Tew own the Sutton Creek Cattle Company, a full-service Wagyu cattle ranch. Ken is the past president of the American Wagyu Association, and Julie is presently on the board of directors.

The farm has a USDA-approved embryo quarantine facility approved for most countries worldwide, and they sell embryos worldwide.

Since 2008, they have used Ramaekers Adult Immune Primer Immune Support for stress management. They have experienced improved wellness in their cow-calf process.

In the ET operation, they have observed an increase in the average number of embryos, and the embryo quality has shown significant improvement.

Until using Dr. Ramaekers’ reproduction protocols, they had never had a flush with 100% of number-one-quality embryos. Now, using Ramaekers Adult Immune Primer Immune Support, 100% #1s are more common than not.

Fertility Study with Ramaekers Livestock Product

6/3/2009

Takana – 143 Wagyu donor cow. Using Ramaekers Adult Immune Primer Immune Support in our embryo production program has increased quality embryo recovery by 35%!

Update: Fertility Study with Ramaekers Livestock Product

06/19/12

Using Ramaekers Adult Immune Primer Immune Support on Takana–143, a 7-year-old Wagyu donor cow. The flush results returned 53 embryos, of which 39 were #1 quality. Julie says they’ve never used a better product for Improved Embryo Quality and Quantity and have been more than happy with the results.

Julie Barnes

Sutton Creek Cattle Company

LLC Baker City, Oregon

Embryo Flush. Adult Immune Primer Immune Support for Livestock.

Learn More about our Bovine Products